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P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
@Mangan150
Oct 28, 2022 • 7 tweets • 3 min read • Read on X
Exercise kills cancer.

When serum from men who performed a bout of high-intensity exercise was added to cancer cell culture, the cells died. No effect on normal cells.

Every time you exercise with intensity, you're inhibiting cancer. Image
The anti-cancer effect may be due to reduced levels of IGF-1 (insulin-like growth factor) and/or increased levels of IGF-1 binding protein.
ncbi.nlm.nih.gov/pmc/articles/P… Image
High levels of physical activity are associated with reduced rates of many types of cancer.

In some cases as little as half the risk.
pubmed.ncbi.nlm.nih.gov/27183032/
Oxytocin mediates the beneficial effects of exercise training on breast cancer

Exercise robustly increases levels of the hormone oxytocin, which decreases growth of cancer

physoc.onlinelibrary.wiley.com/doi/full/10.11…
Oxytocin promotes rejuvenation and muscle regeneration, and declines with age.

There are ways to raise it

Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age

One of the modulators was oxytocin

ncbi.nlm.nih.gov/pmc/articles/P…
High intensity exercise reduces colon cancer cell growth.

Each bout of intense exercise inhibits cancer.

One more reason to exercise. Image

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More from @Mangan150

P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jul 28
The cholesterol hypothesis has been wreaking havoc on human health for 75 years.

This is the idea that higher cholesterol levels, especially LDL, are causally linked to “clogged arteries” and heart disease.

Let’s debunk once again:
Optimal total cholesterol levels are higher in than what current medical dogma states.
Lowering cholesterol is a bad idea if you care about brain health:
Read 8 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jul 23
The two words that matter most for those who want to improve their health, mood, energy levels and quality of life:

Body composition.

Let’s define it:
Body composition refers to the components that make up your total weight.

There are a few ways to think about the components, the best one in my view being the three-compartment model which includes:

Bone
Fat
Fat-free mass
Fat free mass includes both muscle and organs.

When we talk about getting to and maintaining a low body fat %, it’s generally calculated as:

Fat mass divided by total weight (all three components).
Read 7 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jul 9
The most common reason older men have lower testosterone levels?

It’s not because they’re older.

It’s because they’re fat.
25% of men over 75 have T levels on par with high T young men.

What's stopping all men from having T levels that high?

Carrying excess body fat, and not training correctly.
I think a lot of men (and their doctors) are too quick to jump on the TRT wagon.

Get rid of excess body fat and build a little muscle…

And odds are good you could have naturally high T levels.
Read 4 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jun 17
If you’re going to take away one core idea from reading my posts, it should be this:

Metabolic health = controllable health.
A second core idea is that WHAT you can control by getting in, and staying in good metabolic health is… a lot.

We’re talking about obesity, diabetes, heart disease, fatty liver, visceral fat and many types of cancer.
A third idea:

Your body composition, meaning the relative degree to which you’re lean and muscular, is highly linked to your metabolic health.

If you’re lean (not skinny-fat, overweight or obese) and have some muscle, it’s highly unlikely that you’re in poor metabolic health.
Read 9 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Apr 16
A friend asked ChatGPT what were the most important non-consensus things it has picked up in health, longevity, and healthspan.

First 4 are things I've been talking about a long time.

I'm kinda stunned.

In the follow up, the Chat gave me credit.Image
Image
ChatGPT references

1. Iron as a longevity target

The fine control of body iron stores would be a wise strategy for chemoprevention of several diseases. Image
Glycine and aging: glycine extends lifespan. Image
Read 5 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Apr 14
More muscle means lower risk of diabetes

Every 1% decrease in appendicular (legs and arms) muscle mass in proportion to body weight is associated with 30% increased risk of diabetes.

Build muscle and stay healthy. Image
In reality, the increased risk of prediabetes and diabetes with age is almost entirely due to

*increased body fat
*less muscle
*less exercise

Don't gain body fat, build muscle with resistance training, and stay physically active.
You lose muscle as you age.

In old age, someone can have lost 50% of the muscle they had when young.

You can prevent this through resistance training.

Get plenty of protein too. Image
Read 4 tweets

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