“Diabetes Drug Stops Prostate Cancer From Coming Back”

The most profoundly important work in medicine is the study of repurposed medications. Many are out of patent and have no financial basis to get “evidence based” studies of $1 billion dollars. scitechdaily.com/diabetes-drug-…

Repurposing Drugs for
Prostate Cancer Treatment
In 2018, Dr. Beste Turanli et al. list of repurposed drugs for prostate cancer treatment:

Dexamethasone-steroidal, anti-inflammatory
Aspirin (ASA)—COX-1 and COX-2 inhibitor
Diclofenac NSAID—COX-2 inhibi-tor
Celecoxib NSAID—COX-2 inhibitor
Minocycline, doxycycline, tetracycline-Antibiotic, anti-inflammatory
Niclosamide-antiparasitic, potent
Wnt/ß-catenin inhibitor
Itraconazole-antifungal; reversed drug resistance by inhibiting P-glycoprotein, Hedgehog, and Wnt/ß-catenin pathways; inhibits angiogenesis
Digoxin-cardiology drug used for congestive heart failure
Valproic acid-HDAC inhibitor used for seizure disorder
Statins-HMG-CoA reductase in-hibitors; inhibit mevalonate path-way; used for reducing cholesterol
Mifepristone-progesterone-recep-tor blocking drug (PR), used as an abortion drug
Disulfiram-treatment of alcohol addiction
Metformin—popular anti-diabetic drug.

Citation: Turanli, Beste, et al. "Drug repositioning for effective prostate cancer treatment." Frontiers in Physiology 9 (2018).

For over seven centuries, the fishermen of Oostduinkerke, Belgium, have been training sturdy draft horses to assist them in catching shrimp.

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These horses, often weighing more than 2,000 pounds, are perfectly suited for wading through the chilly waters of the North Sea. However, despite its rich history, Oostduinkerke remains the last place on Earth where this unique fishing method is still practiced.

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Shrimp fishing on horseback is considered one of the most challenging fishing techniques ever devised, as it demands expertise in handling both massive horses and delicate shrimp.

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A bullet vs A Prince Rupert's Drop.

A THREAD 🧵

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The Fascinating Mechanics of Prince Rupert’s Drop

Prince Rupert’s Drop is a remarkable demonstration of material science and physics, showcasing the fascinating interplay of stress, structure, and energy. This seemingly simple glass object—a teardrop-shaped piece of solidified glass—holds a secret: it combines extreme strength with profound fragility, depending on where and how it’s tested.

What is Prince Rupert’s Drop?

Prince Rupert’s Drop is created by dropping molten glass into cold water. The rapid cooling causes the outer layer of the glass to solidify almost instantaneously, while the interior cools more slowly. This process induces significant internal stresses in the glass, resulting in the drop’s unique mechanical properties. The structure consists of two main parts:
1.The Bulb: The rounded, thicker end of the drop is extraordinarily strong.
2.The Tail: The thin, extended end of the drop is incredibly fragile.

Why Is the Bulb So Strong?

The strength of the bulb arises from compressive stress. During formation, the outer surface of the glass cools and hardens first, trapping the inner material, which continues to contract as it cools. This creates a state where the outer layer is under compression and the inner layer is under tension.

Compressive stress significantly enhances the material’s ability to resist fracture. In the case of Prince Rupert’s Drop, the compressive strength of the glass bulb is so high that it can withstand impacts, including being struck with a hammer, without breaking.

The Fragility of the Tail

While the bulb is incredibly strong, the thin tail of the drop is under extreme tensile stress. Glass is inherently much weaker in tension than in compression. A slight nick or disturbance to the tail acts as a stress concentrator, causing the entire structure to rapidly release its stored energy. This results in the drop shattering into countless tiny fragments almost instantly.

The phenomenon is explained by the propagation of cracks. Any disturbance to the tail initiates a stress wave that travels through the drop at speeds of up to 1,450 meters per second (faster than the speed of sound in glass), disintegrating it completely.

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Applications and Relevance

Prince Rupert’s Drop serves as a dramatic illustration of material properties like stress distribution, energy storage, and fracture mechanics. It has applications in:
•Material Science Education: A vivid way to teach the principles of stress and fracture mechanics.
•Engineering: Inspiring the design of materials and structures with tailored stress distributions to enhance strength and durability.
•Shock-Absorbing Materials: Lessons from the compressive stress distribution in the bulb could inform the development of robust, impact-resistant materials.

Experimental Studies

Modern studies on Prince Rupert’s Drop leverage high-speed photography and advanced computational models to analyze the stress distribution and fracture dynamics. Key findings include:
•The outer compressive layer is only microns thick, but it significantly contributes to the drop’s strength.
•The release of stored energy during fracture creates a cascading effect, making the disintegration nearly instantaneous.

Prince Rupert’s Drop is a perfect example of how materials can exhibit seemingly contradictory properties of strength and fragility. Its study bridges art, physics, and engineering, offering insights into stress management and fracture behavior that can be applied to modern technological advancements. Despite its simplicity, this 17th-century curiosity continues to captivate scientists and engineers alike, proving that even the smallest objects can reveal profound scientific truths.

Does TikTok Cause Cognitive Decline? A Critical Examination of Research.

A THREAD 🧵🪡

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In recent years, the rise of short-form content platforms like TikTok has prompted discussions about their potential impact on cognitive health.

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A widely debated topic is whether the platform’s fast-paced, hyper personalized AI algorithm-driven content consumption contributes to what some users term “brain rot”—a colloquial term for reduced attention span, memory retention, or critical thinking skills.

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A University of Michigan study published in Science Advances examined the effects of “content switching” on brain function, finding that frequent transitions between short, unrelated content streams can disrupt sustained attention and impair memory consolidation (Mark et al., 2021).

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This is the story of how Edward Bernays with the help of his uncle Sigmund Freud changed your mind in ways that you may never discover.

In this 4 part series The Century of the Self you will begin to see how we live in the Bernays world.

Part 1:

Edward Bernays.

Part 2:

Edward Bernays.

Part 3:

This is one of the most important movies you can watch at this very moment.

Take the hour and learn about the Edward Bernays world you and I live in.

From a VHS tape for you to see today.

Be ready to understand how you and I have been played.

This is a continuation of the most important movies you can watch at this very moment.

Take the hour and learn about the Edward Bernays world you and I live in.

From a VHS tape for you to see today.

Be ready to understand how you and I have been played.

This is a part 3 of the most important movies you can watch at this very moment.

Take the hour and learn about the Edward Bernays world you and I live in.

From a VHS tape for you to see today.

Be ready to understand how you and I have been played.